Author(s): Fangyuan Kong, Xiaohan Zhu, Wenzhen Lin, Mengying Mao and Zhengwei Huang
Among the small leucine rich proteoglycans (SLRPs), osteoadherin (OSAD), also called osteomodulin (OMD), is one of the proteoglycans that only distribute in mineralized tissues. In recent years, the research on OSAD/OMD has focused on its expression characteristics in osteogenic differentiation, including its distribution in tissues, its expression in osteo/odontogenic differentiation and its possible mechanism involved. In this paper, we searched PubMed database for English scientific papers from 2000 to 2020 with the keywords of osteoadhesin, osteomodulin, osteogenic differentiation, SLRPs and BMP2. It is concluded that OSAD/OMD plays a positive role in the growth and differentiation of osteoblasts, and its mechanism involves a variety of signal pathways. It is believed that the study of the role of OMD in biomineralization can shed light on regulating osteogenesis in bone tissue engineering.
